Immunogenic bacterial vesicles with outer membrane proteins

Details Immunogenic bacterial vesicles with outer membrane proteins Immunogenic bacterial vesicles with outer membrane proteins

A - Human Necessities

61

K

A61K 39/095 (2006.01) C12N 15/03 (2006.01)

Patent

CA 2584778

Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.

L'invention concerne la neutralisation de l'homologue méningococcique mltA donnant des bactéries libérant de manière spontanée des vésicules riches en protéines de la membrane externe immunogènes et pouvant éliciter des réponses d'anticorps à protection croisée à titres bactéricides supérieurs à ceux des vésicules de la membrane externe (OMV) préparées au moyen de procédés de production normaux. Par conséquent, l'invention concerne une bactérie possédant une mutation de neutralisation de son gène mltA. L'invention concerne également une bactérie possédant: (i) une paroi cellulaire renfermant du peptidoglycane; et (ii) n'exprimant pas une protéine possédant l'activité de transglycosylase lytique de la protéine MltA. L'invention concerne également des compositions renfermant des vésicules qui, pendant la culture de bactéries selon l'invention, sont libérées dans le milieu de culture.

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