A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/09 (2006.01) A61K 39/095 (2006.01) A61K 39/108 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C08B 37/00 (2006.01) C08L 5/00 (2006.01)
Patent
CA 2340692
Novel immunogenic .beta.-propionamido-linked polysaccharide- and N- propionamido-linked oligosaccharide-protein conjugates are provided as well as method of producing the conjugates. The conjugation procedure is simple, rapid, reproducible and applicable to a variety of polysaccharides or oligosaccharides derived from bacterial species, yeast, cancer cells or chemically synthesized. Vaccines and methods of immunization against infection or cancer using the immunogenic .beta.-propionamido-linked polysaccharide- and .beta.-propionamido-linked oligosaccharide-protein conjugates are also disclosed.
L'invention concerne des conjugués immunogènes de protéine, et de polysaccharide à liaison bêta-propionamido ou d'oligosaccharide à liaison N-propionamido, ainsi qu'un procédé relatif à l'élaboration des conjugués considérés. La procédure de conjugaison est simple, rapide, reproductible et applicable à une variété de polysaccharides et d'oligosaccharides dérivés d'espèces bactériennes, de levure ou de cellules cancéreuses ou bien obtenus par synthèse chimique. L'invention concerne en outre des vaccins et des procédés d'immunisation contre l'infection ou le cancer, faisant appel aux conjugués considérés.
Huang Chun-Hsien
Michon Francis
Uitz Catherine
Baxter Healthcare S.a.
North American Vaccine Inc.
Sim & Mcburney
LandOfFree
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