Immunogenic cell envelope preparations

Details Immunogenic cell envelope preparations Immunogenic cell envelope preparations

A - Human Necessities

61

K

167/135, 195/73

A61K 39/10 (2006.01)

Patent

CA 1126155

ABSTRACT An antigenically-active cell envelope fraction from bacterial cells, especially Bordetella pertussis, may be isolated by disrupting the cells, separating the cell envelope from the other cell components, extracting the separated envelopes with a solution of a zwitterionic surfactant and precipitating the cell envelope preparation from the resulting extract by the addition of a lower alkyl (C1 to C5) alcohol, preferably ethanol. The preferred extractant is an N, N, N-trialkyl zwitterionic compound, especially an N, N, N-trialkyl-.alpha.-amino acid or an N, N, N-trialky amine oxide. The cell envelope fraction obtained from B. pertussis is highly protective against whole bacteria when tested by standard vaccine mouse potency assay and has a greatly reduced lipopolysaccharide content compared with either whole cells or crude cell envelopes, greatly reducting the risk of undesirable side-effects from vaccination.

321817

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