A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/129, 167/44
A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 39/44 (2006.01) A61K 45/00 (2006.01)
Patent
CA 1275042
TITLE: IMMUNOGENIC COMPLEX, A METHOD FOR PRODUCING THE SAME, AND THE USE THEREOF AS AN IMMUNE STIMULANT, VACCINES AND REAGENTS ABSTRACT OF THE DISCLOSURE The invention relates to an immunogenic complex comprising a carrier molecule prepared by mixing viruses, mycoplasmas, bacterias, animal cells or proteins or pep- tides having hydrophobic regions with one or more solubi- lizing agents, whereby a complex having been formed between proteins or peptides and solubilizing agents, whereafter the proteins or the peptides have been separated from the solubilizing agent in the presence of a glucoside solution which con- tains one or more glycosides having hydrophobic and hydrophilic regions in a concentration of at least the critical micellular concentration, or alternatively have been separated from the solubilizing agent and transfer- red directly to the aforementioned glycoside solution, and the carrier molecule being bound to one or more molecules selected from peptides, proteins, carbohydrates, lipoproteins, glycolipides or small molecules, such as biotine, by coupling with known methods between functional coupling groups in the bound molecules and functional groups in the peptides or the proteins in the carrier molecule. The invention also relates to a method for preparing such immunogenic complexes and to immuno- stimulating compositions, vaccines and reagenses con- taining such complexes.
493583
Fetherstonhaugh & Co.
Morein Bror
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