Immunogenic complexes, in particular iscoms

Details Immunogenic complexes, in particular iscoms Immunogenic complexes, in particular iscoms

C - Chemistry, Metallurgy

07

J

C07J 63/00 (2006.01) A61K 39/095 (2006.01) A61K 39/165 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) C07H 15/256 (2006.01) C07K 14/12 (2006.01) C07K 14/195 (2006.01) C07K 14/22 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2094600

The invention relates to immunogenic complexes such as two-dimensional lamellae having a honeycomb structure and in particular three-dimensional iscoms, which immunogenic complexes are composed of at least one sterol, one saponin and, in the case of iscoms, also a phospholipid and also, optionally, at least one antigen generating an immune reaction. The saponin used is at least one of the fractions which are derived from Quil A by means of hydrophobic interaction chromatography and have the designations QA 1 to QA 23, as is shown in the figure by the numerals 1 to 23. Preferably, the saponin used is one or more of the fractions derived from Quil A having the designations QA 3, QA 17 and QA 23. As well as relating to the immunogenic complex, the invention also relates to the specific method of preparation of the relevant Quil A fractions, to vaccines which contain such immunogenic complexes and to kits which contain, on the one hand, an (empty) immunogenic complex and, on the other hand, one or more antigenic proteins or peptides having a hydrophobic fragment which may or may not have been synthetically introduced.

L'invention concerne des complexes immunogènes comme des lamelles bidimensionnelles ayant une structure en forme de nid d'abeille et, en particulier, des iscoms tridimensionnels. Ces complexes sont composés d'au moins un stérol, d'une saponine et en plus, dans le cas des iscoms, d'un phospholipide et aussi, facultativement, d'au moins un antigène donnant lieu à une réaction immunitaire. La saponine utilisée est au moins une des fractions de Quil A obtenues à l'aide de la chromatographie hydrophobe et qui portent les désignations QA 1 à QA 23, tel qu'indiqué par les chiffres 1 à 23 dans la figure. De préférence, la saponine utilisée correspond à l'une ou à plusieurs des fractions de Quil A ayant les désignations QA 3, QA 17 et QA 23. En plus de concerner le complexe immunogène, l'invention a aussi trait à la méthode spécifique de préparation des fractions de Quil A pertinentes, aux vaccins qui comprennent de tels complexes immunogéniques et aux trousses qui contiennent, d'une part, un complexe immunogène (vide) et, d'autre part, un ou plusieurs peptides ou protéines antigéniques ayant un fragment hydrophobe qui peut ou non avoir été synthétiquement introduit.

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