Immunogenic composition and method of developing a vaccine...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 7/00 (2006.01) A01N 63/00 (2006.01)

Patent

CA 2541511

The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one covalent binding site of myristate on the HIV matrix protein. The present invention contemplates three categories of embodiments: protein or protein fragments, messenger RNA, or DNA/RNA. DNA/RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.

La présente invention porte sur une composition immunogénique, et notamment, sur une composition conçue pour éliciter une réponse immune par rapport à au moins un site de liaison covalente de myristate sur la protéine matricielle du VIH. La présente invention porte également sur trois catégories de formes d'exécution: une protéine ou des fragments de celle-ci, un ARN messager ou ADN/ARN, sur des compositions contenant des ADN/ARN soit nus, soit recombinants, ainsi que l'utilisation de divers stimulants immunes.

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