Immunogenic composition and method of developing a vaccine...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 39/21 (2006.01) C12N 7/00 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2541501

An immunogenic composition able to provide an immune response to Human Complement Factor H binding on one or more HIV glycoproteins is disclosed, which is characterized by at least one binding site epitope of the glycoproteins. Such immunogenic composition wherein the glycoprotein comprises gp120, gp4l, or both glycoproteins gp120 and gp4l is hereby disclosed. Sialic acid is removed to enhance immune recognition of the composition and to impair Factor H binding. A medication having an inhibitive action on autoimmune response by specific inhibition of the cleavage of C3b by Factor H into inactive cell fragments.

L'invention concerne une composition immunogène pouvant induire une réponse immunitaire à la liaison du facteur H du complément humain avec une ou plusieurs glycoprotéines du VIH, caractérisée par au moins un déterminant antigénique du site de liaison des glycoprotéines. Dans la composition immunogène selon l'invention, la glycoprotéine comprend gp120, gp41 ou gp120 et gp41. L'acide sialique est supprimé pour renforcer la reconnaissance immunitaire de la composition et altérer la liaison du facteur H. Cette invention concerne en outre un médicament présentant une action inhibitrice sur la réponse auto-immune, par inhibition spécifique du clivage de C3b, par le facteur H, en fragments cellulaires inactifs.

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