A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/012 (2006.01) A61K 39/00 (2006.01) A61K 39/018 (2006.01)
Patent
CA 2491704
The present invention provides an immunogenic composition comprising a fusion protein and a saponin adjuvant. The fusion protein comprises a heterologous hydrophobic peptide that is fused to the N-terminus and/or to the C-terminus of a core polypeptide. The core polypeptide comprises at least one protective epitope. The saponin adjuvant in this composition is present in a free form. Also provided are vaccines comprising the immunogenic composition and optionally an additional immunoactive component. Methods for the preparation of such vaccines, and use of the immunogenic composition for the manufacture of a vaccine are provided as well.
Cette invention a trait à une composition immunogène contenant une protéine fusionnée et un additif à base de saponine. Cette protéine fusionnée comprend un peptide hétérologue hydrophobe fusionné au N-terminal et/ou au C-terminal d'un polypeptide noyau. Ce dernier comporte au moins un épitope protecteur. L'additif à base de saponine est présent dans la composition à l'état libre. L'invention, qui porte également sur des vaccins renfermant cette composition immunogène et, éventuellement, un composant immunoactif complémentaire, concerne, de surcroît, des procédés de préparation de ces vaccins ainsi que l'usage qui est fait de la composition immunogène dans la fabrication d'un vaccin.
Delbecq Stephane
Gorenflot Andre Francois
Precigout Eric
Schetters Theodorus Petrus Maria
Akzo Nobel N.v.
Fetherstonhaugh & Co.
Intervet International B.v.
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