C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/106 (2006.01) C07H 21/00 (2006.01) C07K 14/205 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2144307
The invention relates to an immunogenic composition, capable of inducing protective antibodies against Helicobacter infection, characterised in that it comprises: i) at least one sub-unit of a urease structural polypeptide from Helicobacter pylori, or a fragment thereof, said fragment being recognised by antibodies reacting with Helicobacter felis urease, and/or at least one sub-unit of a urease structural polypeptide from Helicobacter felis, or a fragment thereof, said fragment being recognised by antibodies reacting with Helicobacter pylori urease; ii) and/or, a Heat Shock protein (HSP), or chaperonin, from Helicobacter, or a fragment of said protein. The invention also relates to the preparation, by recombinant means, of such immunogenic compositions.
Ferrero Richard
Labigne Agnes
Suerbaum Sebastien
Thiberge Jean-Michel
Institut National de La Sante Et de La Recherche Medicale
Institut National de La Sante Et de La Recherche Medicale (inser
Institut Pasteur
Sim & Mcburney
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