Immunogenic compositions comprising a xenogenic prostate...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2487907

The present invention relates to pharmaceutical/immunogenic compositions and methods for inducing an immune response against tumour-related antigens. More specifically, the invention relates to non-human prostate-specific antigens, more precisely to the non-human prostate-specific P501S, which can be used as xenogeneic antigen in prostate cancer vaccine therapy and as diagnostic agents for prostate tumours in humans, to immunogenic compositions containing them, to methods of manufacture of such compositions and to their use in medicine. Methods for formulating vaccines for immunotherapeutically treating P501S- expressing prostate tumors, prostatic hyperplasia, and prostate intraepithelilial neoplasia (PIN) are also provided.

La présente invention concerne des compositions pharmaceutiques/immunogènes et des procédés destinés à provoquer une réponse immunitaire contre des antigènes associés à des tumeurs. Plus spécifiquement, l'invention concerne des antigènes non humains, spécifiques à la prostate, notamment l'antigène non humain P501S, spécifique à la prostate, pouvant être utilisé en tant qu'antigène hétérologue dans la thérapie de vaccination contre le cancer de la prostate, et en tant qu'agent diagnostique destiné à la détection de tumeurs prostatiques chez l'humain. L'invention concerne également des compositions immunogènes contenant lesdits antigènes, des procédés de fabrication de telles compositions et leur utilisation en médecine. L'invention concerne par ailleurs des procédés de formulation de vaccins destinés au traitement immunothérapeutique de tumeurs prostatiques exprimant P501S, de l'hyperplasie prostatique, et de la néoplasie prostatique intraépithéliale (PIN).

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