Immunogenic compositions containing escherichia coli h7...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/385 (2006.01) A61K 39/108 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/245 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2702856

Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli 0157:H7 flagella will result in prevention of colonization by Escherichia coli 0157:H7 in the animal or a reduction in the amount of Escherichia coli 0157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal.

Cette invention concerne des compositions immunogènes contenant des flagelles d'Escherichia coli O157:H7 comprenant des protéines de fusion et des procédés utilisant lesdites compositions immunogènes. L'induction d'une réponse immunitaire aux flagelles d'Escherichia coli O157:H7 chez un animal permettra de prévenir la colonisation de l'animal par Escherichia coli O157:H7 ou de réduire la quantité d'Escherichia coli O157:H7 infectant l'animal. La composition immunogène préviendra ou réduira l'adhérence d'Escherichia coli O157:H7 aux cellules de l'animal.

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