C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/21 (2006.01) A61K 39/275 (2006.01) A61K 39/285 (2006.01) A61K 39/295 (2006.01) C07K 14/145 (2006.01) C07K 14/15 (2006.01) C07K 16/08 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01) C12N 15/863 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2210294
Attenuated recombinant viruses containing DNA encoding an HTLV antigen such as HTLV env or HTLV1171, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses.
L'invention concerne des virus de recombinaison atténués contenant de l'ADN codant un antigène HTLV tel que du HTLVenv ou HTLV1171, ainsi que des procédés et des compositions utilisant les virus, des produits d'expression de ces derniers, et des anticorps générés par les virus ou les produits d'expression. Les virus de recombinaison peuvent être des virus de recombinaison NYVAC ou ALVAC. Les virus de recombinaison et les produits gènes de ces derniers ainsi que les anticorps générés par les virus et les produits gènes peuvent être utilisés dans un but prophylactique, thérapeutique et diagnostique.
Franchini Genoveffa
Gallo Robert C.
Paoletti Enzo
Tartaglia James
Smart & Biggar
Virogenetics Corporation
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