Immunogenic compositions for gram positive bacteria such as...

A - Human Necessities – 61 – K

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A61K 39/02 (2006.01)

Patent

CA 2575548

The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.

La présente invention concerne l'identification de nouveaux îlots d'adhésine dans les génomes de différentes isolats et sérotypes de Streptococcus du Groupe A et du Groupe B. Les îlots d'adhésine sont considérés comme codant pour des protéines de surface qui jouent un rôle important dans la virulence des bactéries. Ainsi, les protéines des îlots d'adhésine de l'invention, peuvent être utilisées dans des compositions immunogènes pour l'immunisation prophylactique ou thérapeutique contre l'infection par GAS ou GBS. Par exemple, l'invention peut faire intervenir une composition immunogène comprenant une ou plusieurs protéines d'îlots d'adhésine de l'invention.

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