Immunogenic compositions for streptococcus agalactiae

A - Human Necessities – 61 – K

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A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) A61K 39/116 (2006.01) A61K 39/38 (2006.01)

Patent

CA 2537742

This application relates to Group B Streptococcus ("GBS") vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.

L'invention concerne des vaccins contre le streptocoque de groupe B (<= GBS >=) comprenant des combinaisons d'antigènes polypeptidiques GBS dans lesquelles les polypeptides contribuent à la réponse immunologique chez un récepteur. De préférence, les compositions de l'invention comprennent une combinaison d'au moins deux antigènes GBS, ladite combinaison comprenant un antigène GBS 80 ou un fragment de celui-ci. Dans un mode de réalisation, la combinaison peut comprendre entre deux et treize antigènes GBS sélectionnés dans un groupe d'antigènes comprenant GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, et GBS 691.

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