Immunogenic compounds and protein mimics

Details Immunogenic compounds and protein mimics Immunogenic compounds and protein mimics

C - Chemistry, Metallurgy

07

K

C07K 17/00 (2006.01) A61K 39/00 (2006.01) A61P 37/04 (2006.01) C07K 1/04 (2006.01) C07K 1/113 (2006.01) C07K 14/475 (2006.01) C07K 14/59 (2006.01) C07K 14/705 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2659225

The invention provides means and methods for inducing and/or enhancing immunogenic reproducibility and/or immunogenicity of a compound, comprising at least in part restricting the conformation of said compound. The conformation is preferably restricted by the formation of at least one internal bond within said compound. Protein mimics comprising an amino acid sequence bound to a scaffold and/or a carrier, wherein said amino acid sequence comprises at least one internal SS-bridge, are also herewith provided.

Moyens et méthodes permettant d'induire ou d'accentuer la reproductibilité immunogène et/ou l'iimmunogénicité d'un composé consistant au moins en partie à réduire la conformation dudit composé. Cette conformation est de préférence limitée par la formation d'au moins une liaison dans le composé. Sont également décrites des mimiques moléculaires comprenant une séquences d'acides aminés liée à un squelette et/ou à un vecteur, ladite séquence d'acides aminés comprenant au moins un pont S-S interne.

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