Immunogenic glycopeptides for diagnosing pathogenic...

Details Immunogenic glycopeptides for diagnosing pathogenic... Immunogenic glycopeptides for diagnosing pathogenic...

G - Physics

01

N

G01N 33/569 (2006.01)

Patent

CA 2582833

A method for diagnosing an infection in a patient likely to be infected with a pathogenic microorganism, comprising the detection of CD4+ T lymphocytes recognizing at least one glycopeptide derived from said pathogenic microorganism, essentially consisting of a glycosylated T epitope, comprising from 14 to 25 amino acids, among which at least one neutral amino acid is bonded to a disaccharide or to a trisaccharide, and at least 15% of said amino acids are prolines, one of the prolines being located in position -1 to -4, relative to the position of said neutral amino acid.

Méthode permettant de diagnostiquer une infection chez un patient susceptible d'être infecté par un micro-organisme pathogène. Cette méthode consiste à détecter des lymphocytes CD4+ T reconnaissant au moins un épitope T glycosylé comprenant de 14 à 35 acides aminés, parmi lesquels au moins un acide aminé neutre lié à un disaccharide ou à un trisaccharide, et au moins 15 % de ces acides aminés étant des prolines, avec une de ces prolines en position 1 à 4 par rapport à la position dudit acide aminé neutre.

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