Immunogenic hav peptides

Details Immunogenic hav peptides Immunogenic hav peptides

C - Chemistry, Metallurgy

07

K

530/7.08

C07K 7/08 (2006.01) A61K 39/385 (2006.01) C07K 14/10 (2006.01) C07K 17/00 (2006.01) C07K 17/02 (2006.01) G01N 33/576 (2006.01)

Patent

CA 1270099

IMMUNOGENIC HAV PEPTIDES ABSTRACT OF THE DISCLOSURE Synthetic peptides, containing amino acid residues 15 to 21, 75-80 and 101-107 of the hepatitis A virus (HAV) VP1 structural protein sequence, was prepared and chemically conjugated to a protein carrier molecule. The peptide-carrier conjugate, when inoculated into test animals, gives rise to a specific anti-peptide IgG antibody response. These anti-peptide antibodies bind directly to intact hepatitis A virions, bind to purified and denatured VP1, compete with polyspecific antibody derived from human HAV immune sera, and are capable of neutralizing the infectivity of the virus. The peptide is useful as a synthetic subunit immunogen that stimulates an immune response against HAV.

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