Immunogenic hbc chimer particles having enhanced stability

Details Immunogenic hbc chimer particles having enhanced stability Immunogenic hbc chimer particles having enhanced stability

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) A61P 31/12 (2006.01) C07K 14/02 (2006.01) C07K 14/09 (2006.01) C07K 14/15 (2006.01) C07K 14/16 (2006.01) C07K 14/445 (2006.01) C07K 14/47 (2006.01) C07K 14/50 (2006.01) C07K 19/00 (2006.01) C12N 7/00 (2006.01) C12N 9/02 (2006.01) C12N 15/51 (2006.01)

Patent

CA 2420037

A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that is engineered for both enhanced stability of self- assembled particles and the display of an immunogenic epitope. The display of the immunogenic epitope is displayed in the immunogenic loop of HBc, whereas the enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near the carboxy-terminus of the chimer molecule. Methods of making and using the chimers are also disclosed.

La présente invention concerne une protéine chimérique de nucléocapside de l'hépatite B tronquée au C-terminal (HBc) génétiquement modifiée en vue à la fois d'accroître la stabilité des particules autoassemblées et la présentation d'un site antigénique immunogène. La présentation du site antigénique immunogène se trouve dans la boucle immunogène de la HBc, tandis que la stabilité améliorée est obtenue par la présence d'au moins un résidu de cystéine homologue à proximité de la molécule chimérique du C-terminal. L'invention concerne également des procédés de préparation et d'utilisation desdites chimères.

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