Immunogenic hiv peptides for use as reagents and vaccines

Details Immunogenic hiv peptides for use as reagents and vaccines Immunogenic hiv peptides for use as reagents and vaccines

C - Chemistry, Metallurgy

07

K

C07K 14/155 (2006.01) A61K 38/08 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) C07K 7/06 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2439990

Immunogenic HIV peptides and methods of use are provided in which each HIV peptide include epitopes that are immunoreactive with cytotoxic T lymphocytes (CTLs) from HIV-positive individuals and binds to antibodies that are immunoreactive with the assembled class I major histocompatibility complex (MHC) structure. Preferably, the peptide is an isolated or synthetic peptide containing between nine and eleven amino acid residues within specific regions of the HIV genome.

L'invention concerne des peptides VIH immunogènes et des procédés d'utilisation dans lesquels chaque peptide VIH comprend des épitopes immunoréactifs aux lymphocytes T cytotoxiques (CTL) provenant d'individus VIH positif et se lie à des anticorps immunoréactifs avec la structure assemblée de complexe majeur d'histocompatibilité de classe I (CMH). De préférence, le peptide est isolé ou synthétique et contient entre neuf et once résidus d'acide aminé dans des régions spécifiques du génome VIH.

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