C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/104 (2006.01) C07K 14/21 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2165401
The present invention relates to a hybrid protein comprising the Pseudomonas aeruginosa outer membrane protein I (OprI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF), as well as to monoclonal or polyclonal antibodies against this hybrid protein. Both, the hybrid protein and, the antibodies directed to the hybrid protein confer protection against an infection by Pseudomonas aeruginosa to laboratory animals or man.
La présente invention porte sur une protéine hybride constituée de la protéine I (OprI) de la membrane externe de Pseudomonas aeruginosa, laquelle est fusionnée par son extrémité amino terminale à l'extrémité carboxy-terminale de la protéine F (OprF) de la membrane externe de Pseudomonas aeruginosa. L'invention porte également sur des anticorps monoclonaux ou polyclonaux dirigés contre cette protéine hybride. € la fois la protéine hybride et les anticorps dirigés contre cette dernier confèrent une protection contre une infection par Pseudomonas aeruginosa chez des animaux de laboratoire ou chez l'humain.
Broker Michael
Domdey Horst
Hungerer Klaus-Dieter
Knapp Bernhard
von Specht Bernd Ulrich
Behringwerke Aktiengesellschaft
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics Gmbh & Co. Kg
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