C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01) C07H 3/06 (2006.01) C07K 9/00 (2006.01) C07K 14/22 (2006.01) C07K 17/04 (2006.01) C08B 37/00 (2006.01) C12P 19/00 (2006.01) C12P 19/04 (2006.01)
Patent
CA 2146145
The invention is directed at an immunity providing B cell activating molecule derived from a meningococcal lipopolysaccharide (LPS) having at least one epitope, said molecule comprising at least the communal part of the oligosaccharide part (core region) of lipopolysaccharides specific for at least two meningococcal immunotypes, preferably immunotypes L2 and L3 and wherein galactose is absent in the B cell activating part, as well as derivatives of the molecule with immune reaction inducing capacity. The invention is also directed at an outer membrane vesicle provided with a group of polypeptides having at least the immunoactivity of outer membrane proteins (OMP's) bound to a membrane, a polypeptide from the group of said outer membrane vesicles being a membrane anchored OMP or OMP fragment with a mutation in one of the surface loops, preferably in a 2, 3, 5, 6, 7 or 8-loop of a class I OMP. Furthermore, the invention is directed at a vaccine comprising such an outer membrane vesicle and/or lipopolysaccharide, as well as at methods for preparing a lipopolysaccharide and an outer membrane vesicle as described above.
Hoogerhout Peter
Poolman Jan Theunis
Van Der Ley Peter Andre
Ridout & Maybee Llp
Volksgezondheid En Cultuur de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van W
LandOfFree
Immunogenic meningococcal lps and outer membrane vesicles... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunogenic meningococcal lps and outer membrane vesicles..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunogenic meningococcal lps and outer membrane vesicles... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1506181