Immunogenic peptide carrier conjugates and methods of...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 47/42 (2006.01) A61P 37/04 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2549132

The present invention is directed to methods of producing conjugates of peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.

L'invention concerne des procédés pour produire des conjugués d'immunogènes de peptides à molécules porteuses de protéines / polypeptides, qui sont utilisés comme immunogènes, ces derniers étant conjugués aux porteuses de protéines par l'intermédiaires des groupes fonctionnels activés sur les résidus d'aminoacides de la porteuse ou de la molécule de liaison éventuellement fixée, chaque groupe fonctionnel réactif non conjugué ou résidu d'aminoacides étant inactivé par l'intermédiaire d'un coiffage, ce qui permet de retenir la fonctionnalité immunologique de la molécule porteuse, grâce à la réduction de la propension à des réactions non souhaitées qui peuvent rendre le conjugué moins sûr ou moins efficace. De plus, l'invention concerne des produits et des compositions immunogènes contenant lesdits produits immunogènes fabriqués à partir des procédés de l'invention.

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