Immunogenic peptides and methods of use

Details Immunogenic peptides and methods of use Immunogenic peptides and methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C12N 15/12 (2006.01) C12N 15/86 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2642994

The PAGE4 gene is expressed in reproductive tissues, and is expressed in reproductive cancers, such as prostate cancer, uterine cancer, and testicular cancer. Immunogenic PAGE4 polypeptides are disclosed herein, as are nucleic acids encoding the immunogenic PAGE4 polypeptides, vectors including these polynucleotides, and host cells transformed with these vectors. These polypeptides, polynucleotides, vectors, and host cells can be used to induce an immune response to PAGE4. Diagnostic methods to detect PAGE4 are also described.

Le gène PAGE4 est exprimé dans les tissus reproducteurs et dans les cancers de l'appareil reproducteur, tels que le cancer de la prostate, le cancer de l'utérus et le cancer des testicules. L'invention concerne des polypeptides PAGE4 immunogènes ainsi que des acides nucléiques codant pour ces polypeptides PAGE4 immunogènes, des vecteurs comprenant ces polynucléotides et des cellules hôtes transformées avec ces vecteurs. Ces polypeptides, ces polynucléotides, ces vecteurs et ces cellules hôtes peuvent être utilisés pour induire une réponse immunitaire à PAGE4. L'invention concerne également des méthodes de diagnostic destinées à détecter PAGE4.

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