Immunogenic peptides, antibodies and uses thereof relating...

Details Immunogenic peptides, antibodies and uses thereof relating... Immunogenic peptides, antibodies and uses thereof relating...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2082948

Immunogenic peptides containing amino acid residues which define a binding site to a CD4 receptor are disclosed. Antibodies to these peptides are also disclosed. Methods of reducing the ability of a gp120 env protein to bind to CD4 are also disclosed, Methods of treatment and prophylaxis using these antibodies and peptides are also described.

L'invention se rapporte à des peptides immunogènes contenant des résidus d'acides aminés qui définissent un site de liaison avec un récepteur de molécules CD4, à des anticorps dirigés contre ces peptides, à des procédés permettant de réduire la capacité d'une protéine env gp120 à se lier à des molécules CD4, ainsi qu'à des procédés thérapeutiques et prophylactiques utilisant ces anticorps et ces peptides.

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