A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2634480
The present invention pertains to the field of anti-cancer vaccines. More particularly, the invention concerns an optimized polypeptide, which comprises three cryptic tumor peptides with enhanced immunogenicity and comprises the amino acids sequence YLQVNSLQTVYLEYRQVPVYLEEITGYL, for use in an anti-cancer vaccine. Nucleic acids encoding such a polypeptide, as well as complexes and dendritic cells engineered with this polypeptide or a nucleic acid encoding it, are also part of the invention.
La présente invention concerne le domaine des vaccins anticancéreux. Plus particulièrement, l'invention concerne un polypeptide optimisé, constitué de trois peptides tumoraux cryptiques ayant une immunogénicité renforcée et comprenant la séquence d'acides aminés YLQVNSLQTVYLEYRQVPVYLEEITGYL, qui est destiné à être utilisé dans un vaccin anticancéreux. L'invention concerne en outre des acides nucléiques codant pour ce polypeptide, ainsi que des complexes et des cellules dendritiques manipulées avec le polypeptide ou un acide nucléique codant pour lui.
Cornet Sebastien
Kosmatopoulos Konstantinos
Robic
Vaxon Biotech
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