C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/04 (2006.01) A61P 31/04 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2491070
The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.
Cette invention se rapporte à un polypeptide immunogène isolé de la sous-espèce paratuberculosis du Mycobactérium avium, ainsi qu'à des variants de ce polypeptide. Ce polypeptide et ces variants peuvent être utilisés dans des vaccins contre la maladie de Johne et dans des procédés de détection de cette maladie. Des anticorps contre ce polypeptide ou ces variants peuvent être utilisés dans des tests de diagnostic de la maladie de Johne. Cette invention concerne également des polynucléotides codant ce polypeptide et ces variants et des procédés de préparation de ceux-ci.
Dupont Christine
Murray Alan
Dupont Christine
Institut Pasteur
Massey University
Sim & Mcburney
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