Immunogenic polypeptides and monoclonal antibodies

Details Immunogenic polypeptides and monoclonal antibodies Immunogenic polypeptides and monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 9/72 (2006.01) A61K 39/09 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/315 (2006.01) C07K 16/10 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2694466

Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.

L'invention propose des compositions et des procédés pour déclencher une réponse immunitaire contre le Streptococcus pneumoniae. Plus particulièrement, les compositions et les procédés concernent des polypeptides immunogènes, comprenant des fragments de PhtD et des variants de ceux-ci, et des acides nucléiques, des vecteurs et des cellules transfectées qui codent ou expriment les polypeptides. L'invention porte également sur des procédés de fabrication et d'utilisation des polypeptides immunogènes.

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