Immunogenic proteins from genome-derived outer membrane of...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/20 (2006.01)

Patent

CA 2700643

Leptospira outer membrane proteins (OMPs) LP1454, LP1118, LP1939, MCEII, CADF- likel, CADF-like2, CADF-like3, Lp0022, Lp1499, Lp4337, Lp328 or L21 are provided. The OMPS can be used as tools for developing effective vaccines or diagnostic methods for leptospirosis. Expression vectors for the OMP genes are further provided. The antigenic properties of the Leptospira OMPs can be used to create, manufacture or improve vaccines. Vaccines, including but not limited to DNA vaccines, recombinant vaccines, and T-cell epitope vaccines based on the foregoing OMPs are also provided. Methods for producing such vaccines are also provided. Also provided are methods for using Leptospira OMP genes, proteins and antibodies for therapeutic treatment and serological diagnosis techniques. Image

L'invention concerne des protéines de membrane extérieure de Leptospira (PME) LP1454, LP1118, LP1939, MCEII, CADF-type 1, CADF-type 2, CADF-type 3, Lp0022, Lp1499, Lp4337, Lp328 ou L21. Les PME peuvent être utilisées comme outils pour développer des vaccins ou des procédés de diagnostic efficaces contre la leptospirose. Des vecteurs d'expression pour les gènes de PME sont par ailleurs fournis. Les propriétés antigéniques des PME de Leptospira peuvent être utilisées pour créer, fabriquer ou améliorer les vaccins. Des vaccins, y compris, mais sans que cela soit limitatif, des vaccins ADN, des vaccins recombinants, et des vaccins épitopiques de lymphocyte T à base des PME ci-dessus sont également fournis. Des procédés pour la production de tels vaccins sont également fournis. Des procédés d'utilisation de gènes, de protéines et d'anticorps de PME de Leptospira sont également décrits pour un traitement thérapeutique et des techniques de diagnostic sérologiques.

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