Immunogenic proteoliposomes, and uses thereof

Details Immunogenic proteoliposomes, and uses thereof Immunogenic proteoliposomes, and uses thereof

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 9/00 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) C07K 14/16 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2431212

An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The immunogenic transmembrane protein is bound to a ligand which is anchored in the shape. Methods for making the immunogenic proteoliposomes are provided. uses of the proteoliposome are described, including their use as immunogens to elicit immune reaction, and their use in screening assays, including their use as antigens to screen antibody libraries, as well as for drug screening and the identification of ligands.

L'invention concerne un protéoliposome immunogène contenant une protéine transmembranaire ou des complexes oligomères contenant de telles protéines, y compris des glycoprotéines d'enveloppe virale, dans une membrane lipidique entourant une forme sphérique ou ellipsoïdale. Cette forme contient également de préférence un agent attracteur tel que la streptavidine ou l'avidine, et la membrane lipidique contient une fraction qui se lie à l'agent attracteur, p. ex. biotine. La protéine transmembranaire immunogène est liée à un ligand qui est ancré dans la forme. L'invention concerne des procédés de fabrication de ces protéoliposomes immunogènes ; des applications du protéoliposome, y compris comme immunogènes pour déclencher une réaction immunitaire, et dans des techniques de criblage, p. ex. comme antigènes pour cribler des banques d'anticorps, ainsi que dans le criblage de médicaments et l'identification de ligands.

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