Immunogenicity of glucan binding protein

Details Immunogenicity of glucan binding protein Immunogenicity of glucan binding protein

A - Human Necessities

61

K

A61K 39/09 (2006.01) A61K 38/16 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61P 1/02 (2006.01) A61P 31/04 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2480962

Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to S. mutans glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.

L'invention concerne des compositions immunogènes et des vaccins à virus fractionné que l'on utilise dans le traitement de caries dentaires et qui comprennent des protomères peptidiques d'une protéine B de liaison au glucane et des protomères peptidiques d'une protéine B de liaison au glucane en combinaison avec des protomères peptidiques de glucosyltransférase. Font également l'objet de cette invention des procédés de stimulation d'une réponse immunitaire à la protéine B de liaison au glucane S.mutans ou à la glucosyltransférase. Font en outre l'objet de cette invention des procédés d'immunisation d'un mammifère contre les caries dentaires ainsi que des anticorps se liant à des épitopes particuliers d'une protéine B de liaison au glucane ou une glucosyltransférase.

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