C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2520224
The invention provides immunogenicity-reduced antibodies or antibody fragments that bind a human CR1 receptor. The immunogenicity-reduced anti-CR1 antibody of the invention comprises one or more non-human sequences modified to comprise one or more amino acid substitutions so that the immunogenicity- reduced antibody id non-immunogenic or less immunogenic to a human. The invention also provides bispecific molecules comprising such an immunogenicity- reduced anti-CR1 antibody and an antigen-recognition portion that binds a pathogen. The invention further provides methods and compositions for the treatment of diseases or disorders caused by a blood-borne immunogenic pathogen using the bispecific molecule of the invention.
L'invention porte sur des anticorps ou fragments d'anticorps à immunogénicité réduite se fixant au récepteur humain CR1. Lesdits anticorps comportent une ou plusieurs séquences non humaines modifiées pour comprendre une ou plusieurs substitutions d'acides aminés qui les rendent non immunogènes ou moins immunogènes pour l'homme. L'invention porte également sur des molécules bispécifiques comportant le susdit anticorps et une portion de reconnaissance d'antigènes se fixant à un pathogène. L'invention porte en outre sur des méthodes et préparations pour le traitement de maladies et troubles causés par un pathogène immunogène transmis par le sang, et utilisant la susdite molécule bispécifique.
Carr Francis J.
Hamilton Anita A.
Himawan Jeff
Elusys Therapeutics Inc.
Gowling Lafleur Henderson Llp
Himawan Jeff
LandOfFree
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