Immunogens for meningitidis-a vaccines

Details Immunogens for meningitidis-a vaccines Immunogens for meningitidis-a vaccines

C - Chemistry, Metallurgy

07

H

C07H 11/04 (2006.01) A61K 31/702 (2006.01) A61K 39/095 (2006.01) A61P 31/04 (2006.01) C07H 7/00 (2006.01) C07H 13/00 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2606890

An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and which is connected to a second mannose unit through a 1,6-linkage which connects C-6 of the first unit to C-1 of the second unit, wherein the 1,6-linkage comprises a phosphonate. Related methods of making such compounds, analogous compounds, or intermediates thereof are also disclosed.

Selon l'invention, un oligosaccharide utile pour un vaccin contre la méningite A contient une première unité de mannose présentant un bras écarteur dans la configuration alpha à la position C-1. Ce bras écarteur, qui peut se conjuguer à une protéine, est lié à une seconde unité de mannose par une liaison 1,6- qui lie le C-6 de la première unité au C-1 de la seconde unité. La liaison 1,6- comprend un phosphonate. L'invention concerne des méthodes associées de production desdits composés, de composés analogues, ou de leurs intermédiaires.

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