C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/765 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07F 9/6561 (2006.01) C07K 14/435 (2006.01) C07K 16/44 (2006.01) G01N 33/94 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2151543
Methods are described for the rapid synthesis in satisfactory yield of methyl ecgonine phenylphosphonates as analogues of transition states for the hydrolysis of the benzoyl ester of an ecgonine derivative, namely cocaine, and their linking to carrier proteins, for the purpose of using them as immunogens. The resulting immunogens elicit the formation in experimental animals of antibodies able to promote the hydrolysis of cocaine. Both these catalytic anti-cocaine antibodies and the immunogens themselves are potentially useful for the treatment of individuals seeking to avoid the pharmacological effects of cocaine and in diagnostic applications.
Barber Brian H.
Den Hollander Neil
Krepinsky Jiri J.
Meah M. Younus
Barber Brian H.
Den Hollander Neil
Governing Council Of The University Of Toronto (the)
Krepinsky Jiri J.
Meah M. Younus
LandOfFree
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