Immunoglobulin constructs

Details Immunoglobulin constructs Immunoglobulin constructs

C - Chemistry, Metallurgy

07

K

C07K 16/32 (2006.01)

Patent

CA 2706200

The present invention relates to protein and polypeptide constructs that comprise single variable domains that are linked to an Fc portion. The immunoglobulin constructs comprise two polypeptide chains in which each polypeptide chain comprises two or more single variable domains that are linked, usually via a suitable hinge region or linker, to one or more constant domains that, together, form an Fc portion. The invention also relates to polypeptide chains that form part of such constructs and/or that can be used to form such constructs. The invention further relates to nucleotide sequences and nucleic acids that encode or can be used to express such constructs or polypeptide chains; to methods for producing such constructs and polypeptides chains; to compositions (and in particular pharmaceutical compositions) that comprise such constructs or polypeptide chains; and to uses of such constructs, polypeptide chains or compositions.

Constructions de protéines et de polypeptides comprenant des domaines variables simples reliés à une partie Fc. La construction d'immunoglobuline comprend deux chaînes de polypeptides comprenant chacune deux domaines variables simples ou plus qui sont reliés, généralement par une région charnière ou un lieur appropriés, à un ou à des domaines constants qui forment ensemble une partie Fc. L'invention concerne également des chaînes de polypeptides faisant partie de telles constructions et/ou qui peuvent être utilisées pour former ces dernières. De plus, l'invention concerne: des séquences nucléotidiques et des acides nucléiques codant pour de telles constructions ou chaînes de polypeptides, ou bien pouvant être utilisés pour exprimer ces séquences et acides; des méthodes d'obtention de telles constructions et chaînes de polypeptides; des compositions (et en particulier des compositions pharmaceutiques) comprenant de telles construction ou chaînes de polypeptides; et les utilisations de ces constructions, chaînes de polypeptides ou compositions.

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