Immunoglobulin fusion proteins

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 39/00 (2006.01) C07K 1/00 (2006.01) C07K 14/475 (2006.01) C07K 14/505 (2006.01) C07K 14/52 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 14/56 (2006.01) C07K 14/565 (2006.01) C07K 14/61 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2379388

The present invention relates to novel methods for making fusion proteins comprising a cytokine or growth factor fused to an immunoglobulin domain. The growth factor/cytokine can be fused directly to an immunoglobulin domain or through a peptide linker. The purified growth factor/cytokine-IgG fusion proteins produced by the novel methods are biologically active and can be used to treat diseases for which the non-fused growth factor/cytokine are useful.

L'invention concerne de nouveaux procédés de production de protéines de fusion comprenant une cytokine ou un facteur de croissance fusionnés à un domaine d'immunoglobine. Le facteur de croissance et la cytokine peuvent être fusionnés directement à un domaine d'immunoglobine ou au moyen d'un peptide lieur. Les protéines de fusion à facteur de croissance purifié et à cytokine-IgG produites par ces nouveaux procédés sont actives sur le plan biologique et peuvent être utilisées dans le traitement de maladies pour lesquelles le facteur de croissance et la cytokine non-fusionnés sont utiles.

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