Immunoglobulin molecules having a synthetic variable region...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C07K 7/18 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2310269

The invention provides modified immunoglobulin molecules, particularly antibodies, that immunospecifically bind a member of a binding pair which immunoglobulins have a variable domain containing one or more complimentary determining regions that contain the amino acid sequence of a binding site for that member of the binding pair, which site is derived from the other member of the binding pair and is not naturally found in the complementary determining region. The invention further provides for therapeutic and diagnostic use of the modified immunoglobulin.

L'invention concerne des molécules d'immunoglobuline modifiées, notamment des anticorps, qui se lient de manière immunospécifique à un élément d'une paire de liaison, lesquelles immunoglobulines présentent une partie variable renfermant une ou plusieurs régions déterminantes de la complémentarité renfermant la séquence nucléotidique d'un site de liaison pour cet élément de la paire de liaison, lequel site est dérivé de l'autre élément de la paire de liaison, et que l'on ne trouve pas à l'état naturel dans la région déterminante de la complémentarité. L'invention concerne également l'utilisation thérapeutique et diagnostique de l'immunoglobuline modifiée.

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