Immunoglobulin variable region cassette exchange

Details Immunoglobulin variable region cassette exchange Immunoglobulin variable region cassette exchange

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) C07K 16/00 (2006.01) C12N 7/00 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2587158

The invention provides methods for generating human antibodies with the specificity of a reference antibody by replacement of portions of the VH and VL sequences of the reference antibody with sequences from human antibody repertoires. The invention also provides novel compositions comprising hybrid immunoglobulin variable domains containing a combination of frameworks (FRs) and CDRs from different antibody clones.

L'invention porte sur des méthodes visant à générer des anticorps humains ayant la spécificité d'un anticorps de référence en remplaçant des parties des séquences VH et VL de l'anticorps de référence par des séquences des répertoires d'anticorps humains. L'invention porte également sur de nouvelles compositions comprenant des domaines variables hybrides d'immunoglobuline contenant une combinaison d'infrastructures (FR) et de CDR à partir de différents clones d'anticorps.

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