Immunokinases

Details Immunokinases Immunokinases

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2553261

A synthetic, soluble, endogenous complex formed from at least one component A and at least one component B, whereby component A comprises a binding domain for extra-cellular surface structures that internalize upon binding of component A of said complex, and component B has a constitutive catalytic kinase activity and effects cell biosynthesis/signalling including cell death after internalization. The complex allows to influence the growth and the physiology of cells. In particular said complex, nucleic acid molecules encoding it, cells transfected or transformed with these nucleic acid molecules are usable for the preparation of medicaments for the treatment of proliferative diseases, inflammatory diseases, allergies and autoimmune diseases.

L'invention concerne un complexe endogène, soluble, synthétique, formé à partir d'au moins un composant A et d'au moins un composant B, le composant A comprenant un domaine de liaison de structures à surface extracellulaire qui s'internalisent lors de la liaison du composant A dudit complexe, le composant B présentant une activité kinase catalytique constitutive et permettant la biosynthèse/signalisation cellulaire, y compris la mort cellulaire après internalisation. Ledit complexe permet d'influencer la croissance et la physiologie de cellules. En particulier, ledit complexe, lesdites molécules d'acides nucléiques codant pour ce dernier, lesdites cellules transfectées ou transformées à l'aide desdites molécules d'acides nucléiques peuvent être utilisés pour la préparation de médicaments destinés au traitement de maladies prolifératives, d'allergies et de maladies auto-immunes.

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