Immunokine composition and method

Details Immunokine composition and method Immunokine composition and method

C - Chemistry, Metallurgy

07

K

C07K 14/46 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2404078

A composition and method for preventing HIV infection of mammalian cells. One aspect of the invention relates to an anti-immunodeficiency virus immunokine capable of binding to a cellular protein in a manner that prevents HIV infection of that cell. The compositions can include either an active bioactive polypeptide, such as native cobratoxin, and/or an inactivated bioactive polypeptide, such as cobratoxin in which one or more of the native disulfide bridges have been prevented from forming. The term "immunokine" is used to refer to an inactivated bioactive polypeptide, whether inactivated by chemical, genetic, and/or synthetic means as described herein, with the proviso that a corresponding active bioactive polypeptide can be included where applicable (e.g., for in vitro use).

L'invention concerne une composition et une méthode permettant de prévenir l'infection à VIH de cellules mammifères. Dans un mode de réalisation, l'invention se rapporte à une immunokine dirigée contre le virus de l'immunodéficience capable se lier à une protéine cellulaire de manière à prévenir l'infection à VIH de cette cellule. Les compositions de l'invention peuvent contenir un polypeptide bioactif, tel qu'une cobratoxine native, et/ou un polypeptide bioactif inactivé, tel qu'une cobratoxine dans laquelle la formation d'au moins un pont disulfure natif a été inhibée. Le terme "immunokine" est employé pour faire référence au polypeptide bioactif inactivé par voie chimique, génétique et/ou synthétique, sous réserve qu'un polypeptide bioactif activé correspondant puisse être inclus, le cas échéant (notamment dans des applicationsin vitro).

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