A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/44 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/12 (2006.01) C07K 16/32 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2249352
The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise a Fab' domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lipid, and a polyethylene glycol derivatized lipid. The invention also provides for growth-inhibiting immunoliposomes that lack growth-inhibiting therapeutic agents and yet are capable of inhibiting the growth and proliferation of target cells.
Immunoliposomes optimisant l'internalisation d'une substance dans des cellules cibles portant un marqueur de surface cellulaire caractéristique. Ces immunoliposomes sont constitués d'un domaine Fab' d'un anticorps qui lie spécifiquement le marqueur caractéristique, d'un lipide amphipathique formant des vésicules et d'un lipide dérivé du polyéthylène glycol. L'invention concerne également des immunoliposomes inhibant la croissance qui ne comprennent pas d'agents thérapeutiques d'inhibition de croissance mais sont néanmoins capables d'inhiber la croissance et la prolifération de cellules cibles.
Benz Christopher C.
Hong Keelung
Kirpotin Dmitri
Papahadjopoulos Demetrois
Park John W.
Smart & Biggar
The Regents Of The University Of California
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