Immunological adjuvants for polysaccharide vaccines

Details Immunological adjuvants for polysaccharide vaccines Immunological adjuvants for polysaccharide vaccines

A - Human Necessities

61

K

167/129

A61K 39/39 (2006.01)

Patent

CA 1322333

ABSTRACT OF THE INVENTION An immunological adjuvant for polysaccharide vaccines is provided whereby polysaccharide antigens are rendered more immunogenic and thus stimulate more antibody production including an IgG response and immunological memory. The adjuvant is comprised of (1) either (A) an emulsion system containing a metabolizable oil, a low molecular weight polyol and lecithin, or (B) an oil-in-water emulsion system containing a light hydrocarbon non-biodegradable oil or a biodegradable oil and a detergent and (2) a refined detoxified endotoxin. The adjuvant can optionally also contain trehalose dimycolate.

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