Immunological complex, its preparation and its use

Details Immunological complex, its preparation and its use Immunological complex, its preparation and its use

C - Chemistry, Metallurgy

12

P

167/129, 167/139

C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) G01N 33/535 (2006.01) G01N 33/536 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01) G01N 33/80 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1329545

Abstract The invention relates to an immunological complex of two primary antibodies, which have been conjugated to form a cyclic tetramer with two linker antibodies directed against the Fc-fragments of the primary antibodies. Preferably, the complex is bifunctional, that is to say, that it contains two different primary antibodies, one of which is preferably directed to a detectable substance, such as an enzyme, e.g. peroxidase, and the other is directed to any desired antigen. A tetrameric complex of this kind may be used as a labelled antibody in immunoassays. Further, the invention relates to processes for preparing the complexes and for using the complexes in immunological reactions. Finally, the invention relates to drugs containing a complex according to the invention, as the complexes may be used to direct certain active principles to target cells.

535725

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