Immunological composition for detection of bladder cancer...

G - Physics – 01 – N

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G01N 33/574 (2006.01) C12Q 1/04 (2006.01) G01N 1/30 (2006.01) G01N 33/577 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2266577

The present invention relates to the detection of cancer markers. More particularly, to bladder cancer; to immunological compositions to diagnose, assess or prognose cancer in a human patient; to non-invasive diagnostic methods for bladder cancer. More specifically, the invention relates to immunological compositions for the non-invasive, specific and sensitive detection of bladder cancer. In addition, the invention relates to a method of preparing shedded cells from the bladder for immunocytological analysis. Particularly, the invention relates to a method of preparing cells obtained from a urine sample for urogenital cancer detection and more particularly for bladder cancer detection. Kits for bladder cancer diagnosis are also disclosed.

L'invention porte sur la détection de marqueurs du cancer et plus particulièrement du cancer de la vessie; sur des compositions immunologiques servant à diagnostiquer, évaluer ou pronostiquer le cancer chez l'homme. Elle porte plus spécifiquement sur des compositions immunologiques permettant la détection non invasive, spécifique et sensible du cancer de la vessie. Elle porte en outre sur un procédé de préparation de cellules de desquamation provenant de la vessie à des fins d'analyse immunocytologique, et en particulier sur un procédé de préparation de cellules extraites d'échantillons d'urine en vue de la détection de cancers du système urogénital et plus particulièrement de la détection de cancers de la vessie. L'invention porte également sur des trousses servant au diagnostic du cancer de la vessie.

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