Immunological detection of organophosphates

Details Immunological detection of organophosphates Immunological detection of organophosphates

C - Chemistry, Metallurgy

07

K

C07K 16/44 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C07C 69/708 (2006.01) C07D 317/30 (2006.01) C07D 319/06 (2006.01) C07F 9/547 (2006.01) C07F 9/6571 (2006.01) C07F 9/6574 (2006.01) C12N 5/18 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A62D 3/00 (2006.01)

Patent

CA 2117536

The invention provides novel organophosphate compounds of formula (I), wherein X is selected from the group consisting of R-O-, R-S- and R-NH-, where R is an optionally substituted aromatic or heterocyclic group, or an optionally substituted alkyl or alkenyl group; Y is O or S; R1 is H or alkyl; and R2 is a group of the formula -(CH2)n- wherein n is an integer of from 0 to 10, or branched chain alkylene, or a group of the formula R3-O-R4 wherein R3 and R4 are both straight or branched chain alkylene, and salts and esters thereof. These compounds are structurally similar to organophosphate pesticides, but may be conjugated to antigenic macromolecules. The invention therefore also provides immunoconjugates for use in preparing antibodies or fragments thereof which are capable of binding to "parent" organophosphate compounds and also the antibodies thus prepared. Such antibodies can be polyclonal or monoclonal with monoclonal antibodies being preferred. A method for detecting the presence of an organophosphate in a simple, and assay kits therefor are also provided, the method comprising the step of assaying the sample with an antibody or fragment thereof as provided by the invention. For such methods, the antibody can optionally be labelled or bound to a support or both. The methods of the invention are applicable to all classes of organophosphates.

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