Immunological detection of prions

Details Immunological detection of prions Immunological detection of prions

C - Chemistry, Metallurgy

12

N

C12N 15/70 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12N 15/06 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2280791

The presented invention relates to monoclonal antibodies useful in sensitive and specific immunological assays for the identification of prions in various tissues and body fluids, the production of such monoclonal antibodies by means of immunisation of PrP0/0 mice by means of a new recombinant fragment of PrP and the use of the antibodies, e.g. for therapeutic and preventive treatments of humans and animals suffering from prion diseases.

La présente invention concerne des anticorps monoclonaux, utiles dans des dosages immunologiques spécifiques, sensibles et destinés à l'identification de prions dans divers tissus et fluides organiques, la production de tels anticorps monoclonaux au moyen de l'immunisation de souris PrP?0/0¿ à l'aide d'un fragment recombiné de PrP, ainsi que l'utilisation de ces anticorps chez l'homme et l'animal, par exemple dans des traitements préventifs et thérapeutiques des maladies à prions.

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