C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) A61K 38/00 (2006.01) A61K 38/03 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2481952
The present invention relates to immunogenic compositions and peptides comprising residues 4-10 (FRHDSGY) of the amyloid peptide Abeta42. The invention further relates to antibodies that bind to the Abeta(4-10) antigenic determinant. The invention provides methods for treating Alzheimer's disease and for reducing the amyloid load in Alzheimers patients. The invention also relates to methods for designing small molecule inhibitors of amyloid deposition.
La présente invention concerne des compositions immunogènes et des peptides comprenant des résidus 4-10 (FRHDSGY) du peptide amyloïde Abeta¿42?. L'invention concerne également des anticorps qui se fixent au déterminant antigénique d'Abeta ¿(4-10)?. L'invention concerne des méthodes de traitement de la maladie d'Alzheimer et de réduction de la charge amyloïde chez des patients atteints de la maladie d'Alzheimer. L'invention concerne des méthodes de conception de petites molécules inhibitrices de dépôt amyloïde.
Mclaurin Joanne
St. George-Hyslop Peter
Sim & Mcburney
The Governing Council Of The University Of Toronto
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