Immunological methods to modulate myostatin in vertebrate...

Details Immunological methods to modulate myostatin in vertebrate... Immunological methods to modulate myostatin in vertebrate...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2323607

Immunological compositions and methods for reducing myostatin activity in vertebrate subjects are disclosed. The compositions include myostatin peptide immunogens, myostatin multimers and/or myostatin immunoconjugates capable of eliciting an immune response in a vertebrate subject to which the compositions are administered. The methods are useful for the treatment of a wide variety of disorders.

L'invention concerne des compositions et des techniques immunologiques qui permettent de diminuer l'activité de la myostatine chez les vertébrés. Les compositions comprennent des immunogènes constitués d'un peptide dérivé de la myostatine, des multimères de myostatine et/ou des immunoconjugués de myostatine, capables de provoquer une réponse immunitaire chez le vertébré auxquels elles sont administrées. Les techniques sont utiles pour traiter des pathologies très diverses.

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