Immunological purging of tumor cells from bone marrow using...

Details Immunological purging of tumor cells from bone marrow using... Immunological purging of tumor cells from bone marrow using...

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 35/28 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01) C12N 5/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2147010

A method is described for the immunological purging of tumor cells from the bone marrow of a patient having B cell lym- phoma. The purged bone marrow may be used for therapeutic autologous bone marrow transplantation. Microspheres and a plu- rality of anti-B cell monoclonal antibodies are used to remove tumor cells from bone marrow, without removal or lysis of non-tu- mor cells, to a level not detectable by polymerase chain reaction assay.

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