C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 530/7.1
C07K 14/445 (2006.01) A61K 39/015 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1304888
CASE 2 4 1 9 "IMMUNOLOGICALLY ACTIVE POLYPEPTIDES USEFUL FOR THE PREPARATION OF ANTIMALARIAL VACCINES AND OF DIAGNOSTIC KITS FOR THE DETECTION OF ANTISPOROZOITE ANTIBODIES" Abstract Immunologically active polypeptides constituted, towards the N-terminated end, by an Asn-Val-Asp-Pro-Asn- Ala-Asn-Pro sequence repeated three times and, towards the C-terminated end, by at least three quadruplets with an Asn-Ala-Asn-Pro sequence, linked with each other by means of an amidic bond between the end proline of the first sequence, and the initial asparagine of the first quadruplet. Said polypeptides reproduce nearly exactly the sequential structure of the circumsporozoite protein of P. falciparum, and are useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies in clinical samples of malariated persons.
553481
Bernardi Adriano
Bonelli Fabio
Pessi Antonello
Verdini Antonio S.
Bernardi Adriano
Bonelli Fabio
Eniricerche S.p.a.
Pessi Antonello
Robic
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