C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 14/195 (2006.01)
Patent
CA 2693717
The invention provides a composition for use in raising an immune response to P. gingivalis in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject for P. gingivalis infection comprising administering to the subject a composition of the invention
L'invention porte sur une composition destinée à être utilisée pour déclencher une réponse immunitaire à P. gingivalis dans un sujet. La composition comprend une quantité efficace pour déclencher une réponse immunitaire d'au moins un polypeptide ayant une séquence d'acides aminés sensiblement identique à au moins 50 acides aminés, ou une fraction antigénique ou immunogène, d'un des polypeptides correspondant aux numéros matricules choisis dans le groupe constitué par AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 et AAQ67118. L'invention porte également sur un procédé de prévention ou de traitement d'un sujet pour une infection par P. gingivalis, comprenant l'administration au sujet d'une composition de l'invention.
Ang Ching Seng
Dashper Stuart Geoffrey
Reynolds Eric Charles
Veith Paul David
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oral Health Australia Pty Ltd
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